The Calcium Binding Sites of Synaptic Vesicles of the Frog Sartorius Neuromuscular Junction
نویسندگان
چکیده
ALBERTO L . POLITOFF, STEVEN ROSE, and GEORGE D . PAPPAS . From the Department of Anatomy and the Rose F . Kennedy Center for Mental Retardation and Human Development, Albert Einstein College of Medicine, Bronx, New York 10461 and the Marine Biological Laboratory, Woods Hole, Massachusetts 02543 . Dr . Politoffs present address is the Department of Physiology, Boston University School of Medicine, Boston, Massachusetts 02118 .
منابع مشابه
New insights into short-term synaptic facilitation at the frog neuromuscular junction.
Short-term synaptic facilitation occurs during high-frequency stimulation, is known to be dependent on presynaptic calcium ions, and persists for tens of milliseconds after a presynaptic action potential. We have used the frog neuromuscular junction as a model synapse for both experimental and computer simulation studies aimed at testing various mechanistic hypotheses proposed to underlie short...
متن کاملTransmitter release is evoked with low probability predominately by calcium flux through single channel openings at the frog neuromuscular junction.
The quantitative relationship between presynaptic calcium influx and transmitter release critically depends on the spatial coupling of presynaptic calcium channels to synaptic vesicles. When there is a close association between calcium channels and synaptic vesicles, the flux through a single open calcium channel may be sufficient to trigger transmitter release. With increasing spatial distance...
متن کاملTransmitter release is evoked with low probability predominately by calcium flux 2 through single channel openings at the frog neuromuscular junction
39 The quantitative relationship between presynaptic calcium influx and transmitter 40 release critically depends on the spatial coupling of presynaptic calcium channels to 41 synaptic vesicles. When there is a close association between calcium channels and 42 synaptic vesicles, the flux through a single open calcium channel may be sufficient to 43 trigger transmitter release. With increasing s...
متن کاملNew insights into short-term synaptic facilitation at the frog neuromuscular
25 26 Short-term synaptic facilitation occurs during high frequency stimulation, is known to be dependent on 27 presynaptic calcium ions, and persists for tens of milliseconds after a presynaptic action potential. We 28 have used the frog neuromuscular junction as a model synapse for both experimental and computer 29 simulation studies aimed at testing various mechanistic hypotheses proposed to...
متن کاملMacromolecular connections of active zone material to docked synaptic vesicles and presynaptic membrane at neuromuscular junctions of mouse.
Electron tomography was used to view macromolecules composing active zone material (AZM) in axon terminals at mouse neuromuscular junctions. Connections of the macromolecules to each other, to calcium channels in the presynaptic membrane, and to synaptic vesicles docked on the membrane prior to fusing with it during synaptic transmission were similar to those of AZM macromolecules at frog neuro...
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عنوان ژورنال:
- The Journal of Cell Biology
دوره 61 شماره
صفحات -
تاریخ انتشار 1974